The metastasis-promoting role of YWHAZ was further validated in human pancreatic cancer cells. We demonstrated that functional activation of Ywhaz by the gene search vector led to enhanced metastatic capability in mouse pancreatic cancer cells. ![]() Using this strategy, we identified YWHAZ as a key regulator of pancreatic cancer metastasis. Here, we established a high-throughput and piggyBac transposon-based genetic screening platform, which enables either reduced or increased expression of chromosomal genes near the incorporation site of the gene search vector cassette that contains a doxycycline-regulated promoter. Despite the identification of many metastasis-related genes, distinguishing the drivers from numerous passengers and establishing the causality in cancer pathophysiology remains challenging. ![]() Metastasis is a complicated multistep process, which is determined by complex genetic alterations. Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies.
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